Figure 4

Inhibition of prefrontal protein synthesis following trace conditioning impairs consolidation. A, Scheme illustrating the training, intra-mPFC infusion, and retention testing in a novel context 30 days following the training. B, Summary data showing the learning curves for animals during trace fear conditioning. Data is presented as the mean ± SEM for percent freezing during the trace period. C, Percent freezing during the pre-CS, CS and trace periods of the reactivation trial for intra-mPFC anisomycin- and vehicle-infused groups. D, Summary data showing the learning curves of the vehicle- and anisomycin-infused animals during the trace conditioning paradigm. Data is presented as the mean ± SEM for percent freezing during the trace period. Data is presented as the mean ± SEM. *, P < 0.05.