No RNA editing at the second kinase consensus motif in Drosophila synapsin. (A). Schematic representation of the domain structure of the 143 kDa Drosophila synapsin isoform. The A- C- and E-domains are conserved between vertebrates and invertebrates. The Drosophila protein contains two consensus motifs for PKA, one in the A-domain and the other near the E-domain. (B). Comparison of genomic and cDNA sequences of the regions coding for the two kinase target consensus motifs of two wild-type strains. Only the first consensus sequence is modified by RNA editing.