Skip to main content
Figure 6 | BMC Neuroscience

Figure 6

From: Variability of doublecortin-associated dendrite maturation in adult hippocampal neurogenesis is independent of the regulation of precursor cell proliferation

Figure 6

Distribution of dendritic morphologies in other subgroups of cells. A, BrdU/DCX/CR triple immunohistochemistry identifies cells that have just undergone cell division but have terminally exited from the cell cycle. Consequently, at 1 day after BrdU, these cells are found in categories A – D, two thirds in categories A and B. Two days later, about 10% have progressed to more advanced stage E. B, CR as a postmitotic marker in immature granule cells has the limitation that the onset of CR expression varies after exit from the cell cycle (cf. Fig. 3B). As a result, CR-negative DCX-positive cells can be found as late as stage E. However, they were never found in category F. C, in all categories cells without contact to astrocytes were found, but more than half of these cells were in the advanced categories E and F. If put into relation to the distribution of proliferative cells among DCX-positive cells and the absolute numbers (Fig. 4) this implies that during the early period of DCX-expression most cells have contacts with astrocytes but tend to lose this contact with increasing maturation.

Back to article page