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Figure 1 | BMC Neuroscience

Figure 1

From: Effects of lipopolysaccharide-induced inflammation on expression of growth-associated genes by corticospinal neurons

Figure 1

Schematic diagrams showing experimental design and procedures. a. Unilateral application of lipopolysaccharide (LPS) to the pial surface of motor cortex through a cranial burrhole with sham operation on the contralateral side, to investigate the inflammatory response and expression of growth-associated proteins. b. Unilateral LPS application to the pial surface and injection of Cholera toxin B or placement of Fluorogold (FG) (retrograde tracers) into the contralateral corticospinal tract (CST) at C4 or C6 respectively, to identify CST neurons displaying changes in growth-associated protein expression. c. Application to the pial surface of LPS with injection of biotinylated dextran amine (BDA; anterograde tracer) into motor cortex and transection of contralateral CST. LPS application omitted in control animals.

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