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Table 2 Effect of over-expression of wild-type huntingtin on HD-like phenotypes in the YAC128 mouse model of HD.

From: Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease

Phenotype

Percent Difference YAC128 Compared to WT

Percent Difference YAC18/128 Compared to WT

Percent Rescue with WT htt Expression

Significance

Rotarod

-36%

-41%

None

p = 0.5

Activity – 2 Months

+6%

+2%

74%

P = 0.5

Activity – 12 Months

-10%

-6%

47%

P = 0.5

Striatal Volume

-9%

-7%

21%

p = 0.3

Striatal Neuronal Counts

-6%

-3%

38%

p = 0.4

Striatal DARPP-32 Expression

-18%

-14%

22%

p = 0.3

Striatal Neuronal Size

-12%

-2%

87%

p < 0.001