| Â | Mouse | Human | Homologuea |
|---|
Measure | Promoterb | Intergenicc | Scored | Promoterb | Intergenicc | Scored | Completee | Conservedf | Scoreg |
|---|
Total genes | 18071 | 13475 | Â | 19794 | 15178 | Â | 13365 | 516 | Â |
CREB targets | 1050 | 279 | 0.64 | 1389 | 388 | 0.64 | 830 | 356 | 0.83 |
zif268 targets | 1382 | 200 | 0.81 | 1203 | 244 | 0.74 | 1136 | 166 | 0.56 |
% CREB genes | 5.81% | 2.07% | Â | 7.02% | 2.56% | Â | 6.21% | 2.66% | Â |
% zif268 genes | 7.65% | 1.48% | Â | 6.08% | 1.61% | Â | 8.50% | 1.24% | Â |
- a The homologue dataset was contructed using the Homologene resource on the NCBI website (http://www.ncbi.nih.gov).
- b The promoter region is the area from -1,000 to 200 bp relative to transcription start.
- c Intergenic regions refer to an area 50,000 bp away from transcription start. Fewer intergenic regions are available than genes because of gaps in sequencing.
- d The score is determined by the positive predictive value which is a conservative estimate of the fraction of found transcription factor binding sites that are true hits. It is calculated as (%Observed - %Intergenic)/(%Observed).
- eThe complete homologue numbers refer the the number of human/mouse homologous pairs identified using the Homologene resources.
- f The conserved dataset is a subset of the Homologene dataset that consists of only those genes for which homologous pairs contain a conserved binding site.
- g The quality is determined by the positive predictive value which is a conservative estimate of the percentage of found transcription factor binding sites that are true hits. It is calculated as (%Conserved Observed - %Predicted Conserved)/(%Conserved Observed).
