Figure 1From: Intracerebroventricular antisense knockdown of Gαi2 results in ciliary stasis and ventricular dilatation in the ratVentricular volumes and wall surface areas imaged by high resolution MRI in vivo. Upper graph illustrates time-course of unilateral ventricular dilatation in AS-ODN treated rats. The brain is shown from rostral side, i.e. the targeted right lateral ventricle is on the left. The level of coronal MRI images corresponds to ~Bregma -1.0. Graphs below show ventricular volumes (μl) and wall surface areas (mm2) in all treatment groups calculated from consecutive MRI images using the Cavalieri principle. Data represent mean ± SEM, (n = 4–10 animals in each time point). ***, p < 0.001 significantly different from the other ipsi- and contralateral ventricles, one-way ANOVA with Tukey's Multiple Comparison test. AS-ODN, antisense-oligodeoxynucleotide against Gαi2; ODN control, mismatch-oligodeoxynucleotide.Back to article page