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Figure 1 | BMC Neuroscience

Figure 1

From: Intracerebroventricular antisense knockdown of Gαi2 results in ciliary stasis and ventricular dilatation in the rat

Figure 1

Ventricular volumes and wall surface areas imaged by high resolution MRI in vivo. Upper graph illustrates time-course of unilateral ventricular dilatation in AS-ODN treated rats. The brain is shown from rostral side, i.e. the targeted right lateral ventricle is on the left. The level of coronal MRI images corresponds to ~Bregma -1.0. Graphs below show ventricular volumes (μl) and wall surface areas (mm2) in all treatment groups calculated from consecutive MRI images using the Cavalieri principle. Data represent mean ± SEM, (n = 4–10 animals in each time point). ***, p < 0.001 significantly different from the other ipsi- and contralateral ventricles, one-way ANOVA with Tukey's Multiple Comparison test. AS-ODN, antisense-oligodeoxynucleotide against Gαi2; ODN control, mismatch-oligodeoxynucleotide.

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