Figure 8

Pattern of recombination in adult Creb1^D1Cre, CaMKIV^D1Cre and GR^D1Cre mice. Recombination is shown in striatum (a-f), hippocampus (g-l) and cortex (m-r). Recombination is followed by disappearance of CREB (a,b,g,h,m,n), CaMKIV (c,d,i,j,o,p) and GR proteins (e,f,k,l,q,r) in the respective mutants. All animals are homozygous for the respective loxP-modified allele in the case of Creb1^loxP, CaMKIV^loxP and GR^loxP mice. Control animals are devoid of the D1Cre transgene while mutant animals carry the D1Cre trangene, as indicated. The hippocampus CA2 field is indicated by arrowheads. The cortical layers are indicated. Magnification: (a-f) 200×; (g-l) 50×; (m-r) 54×.