Figure 3

Effects of age on cued and reference memory tasks with cued trials conducted first. A and B: Graphs showing the performance, measured as cumulative proximity in tracker system units, of 3 and 26 month old mice within cued trials in the water maze with all animals included in analysis (A) and with 4 aged mice excluded for poorer performance on cued trials than 3 standard deviations from the mean performance in the young (B). C: Graph showing the performance, measured as cumulative proximity in tracker system units, of 3 and 26 month old mice within individual place learning trials with 4 aged mice excluded. D: Graphs showing the performance, measured as cumulative proximity in tracker system units, of 3 and 26 month old mice averaged across all place learning trials. Results are for both when all mice were included (no exclusion) and when 4 old mice were excluded (4 exclusions) from analysis. * p < .05 for difference from 3 month old mice (analysis of variance and Fisher's protected least significant difference post-hoc analysis). A and D (no exclusions): n = 8 for 3 month olds and n = 10 for 26 month old mice. B, C, and D (4 exclusions): n = 8 for 3 month olds and n = 6 for 26 month old mice. Error bars represent SEM.