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Figure 4 | BMC Neuroscience

Figure 4

From: Neurite outgrowth on a fibronectin isoform expressed during peripheral nerve regeneration is mediated by the interaction of paxillin with α4β1 integrins

Figure 4

The LD4 domain of paxillin contributes to α4-mediated neurite outgrowth. Neurite outgrowth of PC12 cells expressing α4 and the different paxillin constructs, measured as in Fig. 1. The data shown are the mean ± SEM of 3 experiments. Note that paxillin over-expression enhances neurite outgrowth, but the paxillin lacking the LD4 domain (LD4pax) does so less effectively than wild-type paxillin (wtpax) or paxillin with Tyr to Phe mutations of the 3 tyrosines (3Ypax) (** = P < 0.05 as compared to the level of outgrowth in cells expressing α4 and wtpax).

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BMC Neuroscience

ISSN: 1471-2202

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