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Table 2 Functional effects of pAMICDYS and pAVP22-MICDYS for diaphragm muscles though intraperitoneal injection

From: Enhanced effect of microdystrophin gene transfection by HSV-VP22 mediated intercellular protein transport

 

C57BL/10

mdx

pAVP22

pAMICDYS

pAVP22-MICDYS

 

(n = 4)

(n = 4)

(n = 3)

(n = 5)

(n = 5)

BM (g)

20.3 ± 1.5

23.8 ± 1.6

22.5 ± 1.5

23.3 ± 1.3

21.8 ± 1.6

sP0 (KN/m2)

215 ± 6.3

90.8 ± 4.3

92.1 ± 5.1

98.7 ± 5.8

145.3 ± 6.9*

  1. Values are means ± SEM; n, number of mice; BM, body mass; sPo, specific maximum isometric tetanic force.
  2. * P < 0.05 versus untreated mdx and treated by pAMICDYS.
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BMC Neuroscience

ISSN: 1471-2202

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