Spinal cord dorsal horn | S1 area of cortex | Hippocampus | |||||||
---|---|---|---|---|---|---|---|---|---|
Naïve | Saline | Bee venom | Naïve | Saline | Bee venom | Naïve | Saline | Bee venom | |
5 min | |||||||||
Ipsil | 2.61 × 10-3 ± 2.21 × 10-3 | 0.50 ± 0.11* | 0.54 ± 0.20† | 2.80 × 10-3 ± 2.80 × 10-3 | 2.56 ± 1.83 | 1.08 ± 0.38 | 0.04 ± 0.03 | 0.58 ± 0.33 | 0.93 ± 0.44 |
Contl | 0.02 ± 0.01 | 0.57 ± 0.31 | 0.52 ± 0.32 | 3.32 × 10-3 ± 3.32 × 10-3 | 0.84 ± 0.30* | 0.61 ± 0.24† | 0.17 ± 0.13 | 0.87 ± 0.31 | 0.81 ± 0.28 |
15 min | |||||||||
Ipsil | 8.49 × 10-4 ± 5.49 × 10-4 | 0.47 ± 0.08** | 0.44 ± 0.09†† | 1.63 × 10-3 ± 1.63 × 10-3 | 0.93 ± 0.30* | 0.49 ± 0.23† | 0.02 ± 0.01 | 0.60 ± 0.42 | 0.55 ± 0.30 |
Contl | 0.02 ± 0.02 | 0.34 ± 0.12** | 0.30 ± 0.07†† | 2.61 × 10-4 ± 2.61 × 10-4 | 0.63 ± 0.28* | 0.95 ± 0.40† | 0.07 ± 0.04 | 0.40 ± 0.08* | 0.32 ± 0.08† |
30 min | |||||||||
Ipsil | 2.50 × 10-3 ± 1.98 × 10-3 | 0.36 ± 0.01*** | 0.32 ± 0.05††† | 1.14 × 10-3 ± 1.14 × 10-3 | 0.52 ± 0.16* | 0.51 ± 0.20† | 4.16 × 10-3 ± 3.43 × 10-3 | 0.50 ± 0.19* | 0.72 ± 0.10† |
Contl | 0.01 ± 0.01 | 0.27 ± 0.10 | 0.25 ± 0.08 | 4.93 × 10-4 ± 4.93 × 10-4 | 0.95 ± 0.16* | 1.48 ± 0.58† | 0.03 ± 0.01 | 0.38 ± 0.13* | 0.75 ± 0.13† |
1 h | |||||||||
Ipsil | 8.45 × 10-4 ± 7.28 × 10-4 | 0.64 ± 0.32 | 0.67 ± 0.26 | 0 | 0.65 ± 0.34 | 0.29 ± 0.07 | 3.95 × 10-3 ± 3.40 × 10-3 | 0.64 ± 0.50 | 0.58 ± 0.42 |
Contl | 7.89 × 10-3 ± 6.95 × 10-3 | 0.36 ± 0.04** | 0.29 ± 0.06†† | 0 | 0.48 ± 0.28** | 0.52 ± 0.22†† | 0.02 ± 0.02 | 0.62 ± 0.41 | 2.23 ± 1.79 |
2 h | |||||||||
Ipsil | 4.71 × 10-4 ± 4.48 × 10-4 | 0.57 ± 0.10* | 0.71 ± 0.22† | 2.61 × 10-4 ± 2.61 × 10-4 | 1.07 ± 0.68 | 0.56 ± 0.40 | 0.02 ± 0.02 | 0.49 ± 0.22 | 0.66 ± 0.28 |
Contl | 5.99 × 10-3 ± 4.26 × 10-3 | 0.27 ± 0.07 | 0.38 ± 0.15† | 0 | 0.57 ± 0.13* | 0.55 ± 0.06† | 0.03 ± 0.03 | 0.52 ± 0.18 | 0.49 ± 0.28 |
4 h | |||||||||
Ipsil | 5.53 × 10-4 ± 3.33 × 10-4 | 0.44 ± 0.16 | 0.53 ± 0.21 | 0 | 0.65 ± 0.37 | 0.82 ± 0.52 | 0.05 ± 0.03 | 0.37 ± 0.08* | 0.59 ± 0.12† |
Contl | 2.40 × 10-3 ± 1.43 × 10-3 | 0.35 ± 0.11* | 0.34 ± 0.09† | 0.07 ± 0.06 | 1.32 ± 0.48* | 1.08 ± 0.16† | 0.07 ± 0.05 | 0.33 ± 0.04 | 0.52 ± 0.25 |
6 h | |||||||||
Ipsil | 1.13 × 10-3 ± 5.75 × 10-4 | 0.60 ± 0.22 | 0.49 ± 0.21 | 6.79 × 10-4 ± 6.79 × 10-4 | 0.37 ± 0.09** | 0.42 ± 0.03†† | 0.04 ± 0.02 | 1.38 ± 0.83 | 1.58 ± 0.68 |
Contl | 6.00 × 10-3 ± 5.12 × 10-3 | 0.49 ± 0.06*** | 0.44 ± 0.03††† | 0.08 ± 0.08 | 0.91 ± 0.53 | 0.60 ± 0.42 | 0.08 ± 0.06 | 1.25 ± 0.30* | 0.93 ± 0.17† |
12 h | |||||||||
Ipsil | 1.59 × 10-3 ± 8.16 × 10-4 | 0.53 ± 0.24* | 0.62 ± 0.18† | 0 | 0.53 ± 0.19** | 0.54 ± 0.17†† | 7.94 × 10-3 ± 5.17 × 10-3 | 0.75 ± 0.09*** | 0.85 ± 0.16††† |
Contl | 1.49 × 10-3 ± 6.99 × 10-4 | 0.45 ± 0.05*** | 0.43 ± 0.06††† | 4.17 × 10-4 ± 4.17 × 10-4 | 0.71 ± 0.46 | 1.02 ± 0.61 | 0.09 ± 0.09 | 1.16 ± 0.44* | 1.28 ± 0.21† |
24 h | |||||||||
Ipsil | 7.32 × 10-4 ± 4.13 × 10-4 | 0.63 ± 0.15* | 0.53 ± 0.26† | 0 | 0.62 ± 0.29 | 1.93 ± 1.52 | 1.97 × 10-4 ± 1.97 × 10-4 | 1.28 ± 0.70 | 0.87 ± 0.40 |
Contl | 1.74 × 10-3 ± 8.96 × 10-4 | 0.39 ± 0.09** | 0.35 ± 0.05†† | 5.15 × 10-4 ± 5.15 × 10-4 | 1.42 ± 0.52* | 0.48 ± 0.05† | 0.05 ± 0.05 | 2.02 ± 0.72 | 0.97 ± 0.22 |
48 h | |||||||||
Ipsil | 5.66 × 10-4 ± 3.37 × 10-4 | 0.33 ± 0.14 | 0.38 ± 0.18 | 1.84 × 10-3 ± 1.84 × 10-3 | 0.08 ± 0.04 | 0.16 ± 0.04† | 7.45 × 10-3 ± 5.32 × 10-3 | 0.76 ± 0.02*** | 0.50 ± 0.04††† |
Contl | 6.04 × 10-3 ± 4.18 × 10-3 | 0.14 ± 0.02* | 0.24 ± 0.05††† | 6.85 × 10-4 ± 6.85 × 10-4 | 0.90 ± 0.83 | 0.88 ± 0.82 | 5.59 × 10-3 ± 5.32 × 10-3 | 0.65 ± 0.16* | 0.36 ± 0.08† |