Figure 2
From: Sodium channel Nav1.6 accumulates at the site of infraorbital nerve injury
Na v 1.6 and caspr staining. A and B. Confocal migrographs of Nav1.6 (red) and caspr (green) staining relationships seen within individual fibers in the normal (A) and lesioned (B) ION. A. Individual fibers within the normal ION show bright Nav1.6 staining (arrowhead) at nodes of Ranvier that are identified as the gap seen between the dense paranodal staining of caspr (arrow). B. Individual fibers within the lesioned ION show alterations in the Nav1.6 and caspr staining relationships that include "heminodes" (small arrowheads) and "split nodes" that vary in the distance seen between the Nav1.6 accumulations (small and large arrows). Some large Nav1.6 accumulations are flanked on both sides by reduced caspr staining (large arrowheads), while other nodes appear more normal (asterick). Scale bars = 5 μm.