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Table 3 Contractile properties of the MCAs.

From: Protein kinase C inhibition attenuates vascular ETBreceptor upregulation and decreases brain damage after cerebral ischemia in rat

  Control     Ro-32-0432    
  RMCA   LMCA   RMCA   LMCA  
  Emax(%) pEC50 Emax(%) pEC50 Emax(%) pEC50 Emax(%) pEC50
S6c 21 ± 4 8.38 ± 0.30 3 ± 2** 6.81 ± 0.01* 7 ± 2* 7.43 ± 0.59 5 ± 3** 6.89 ± 0.16
ET-1 238 ± 19 7.62 ± 0.14 253 ± 28 7.49 ± 0.13 278 ± 11 7.54 ± 0.09 187 ± 12 7.72 ± 0.31
  1. Contractile responses to sarafotoxin 6c (S6c) and endothelin-1 (ET-1) in the right and the left MCA 24 hours after MCAO. Emax is expressed as percent of K+ induced contractions and pEC50 values represent negative logarithm of the agonist concentration producing half maximum response. *P < 0.05, **P < 0.01 compared to control RMCA. P < 0.05 compared to Ro-32-0432 RMCA.