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Figure 5 | BMC Neuroscience

Figure 5

From: Distinct roles of presynaptic dopamine receptors in the differential modulation of the intrinsic synapses of medium-spiny neurons in the nucleus accumbens

Figure 5

Dissection of quinpirole effects using D2 and D3 KO mice. A. A 3D reconstruction of a MSN from a D2 KO mouse is shown with the cell body and dendrites in blue and the axon in red. The area outlined (black rectangle) corresponds to the area imaged in panel B. B. The OG1 image contained four hot spots (numbered). C. Spline scan image. Top panel shows Alexa594, and bottom panel shows OG1. In the OG1 image, only varicosity #4 showed a Ca2+ response. D. In this D2 KO cell, quinpirole facilitated the Ca2+ response. E. 3D reconstruction of a MSN from a D3 KO mouse. The area outlined (black rectangle) corresponds to the area imaged in panel F. F. The area imaged contained three hot spots (numbered). G. Spline scan image. Top panel shows Alexa594, and bottom panel shows OG1. H. In this D3 KO cell, quinpirole inhibited varicosity #2 (*), but had no effect on varicosities #1 and 3.

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