Posttraumatic secondary brain insults exacerbates neuronal injury by altering Metabotropic Glutamate Receptors

BMC Neuroscience

Table 1 Physiological Parameters 1 hour after experiment or injury ( $\bar{x}$ ± s) and mortality of rats (%) in different groups

Group	No. Rats	(AMBP mmHg)	Core Temp (°C)	PaO2 (mmHg)	PaCO2 (mmHg)	PH	SaO2 (%)	Blood sugar (mmol/L)	No. Death	Percentage of Death (%).
Normal control	60	108.7 ± 10.4	37.3 ± 0.8	240.6 ± 30.8	39.4 ± 6.2	7.5 ± 0.1	99.5 ± 0.8	5.2 ± 0.2	0	0
Sham-operated	60	107.2 ± 12.9	37.1 ± 0.8	250.9 ± 25.3	37.2 ± 4.5	7.5 ± 0.2	99.3 ± 1.2	5.3 ± 0.3	0	0
SBI alone	60	110.5 ± 14.9	37.2 ± 0.6	247.5 ± 16.2	39.5 ± 7.4	7.4 ± 0.1	99.6 ± 2.3	5.5 ± 0.7	0	0
DBI alone	60	100.2 ± 16.2	37.7 ± 0.7	234.9 ± 21.8	40.3 ± 8.5	7.4 ± 0.2	99.4 ± 2.2	6.1 ± 0.4	12	20.0
DBI with SBI	71	103.6 ± 13.0	37.2 ± 0.3	226.6 ± 17.9	38.0 ± 6.8	7.3 ± 0.2	98.8 ± 4.3	5.6 ± 0.6	23	32.4 ^a

^a P < 0.05 vs DBI alone group
The table shows the physiological parameters of the rats 1 hour after surgery. There were no changes among groups (P > 0.05) in the measured physiological parameters during the experiment, including MABP, core temperatures, blood gas analysis, and blood glucose. And the table also shows that no rats died in normal, sham-operated control and SBI alone groups. Twelve and 23 of the rats died in DBI and DBI with SBI group respectively. Compared with that in DBI alone group, the mortality of rats in DBI with SBI group was higher (P < 0.05).

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