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Table 1 Squalestatin alters the trafficking of MoPrP105-132 in neuroblastoma cells. The percentage of MoPrP105-132 that co-localised with cellular markers as shown in untreated neuroblastoma cells and cells treated for 24 hours with 1 μM squalestatin. Values shown are mean percent of peptide that co-localises with markers as shown, ± SD, which was calculated after counting a minimum of 3 cells.

From: Squalestatin alters the intracellular trafficking of a neurotoxic prion peptide

 

% Co-localisation with MoPrP105-132

 

Untreated

Squalestatin-treated

CTxB

63% ± 8

5% ± 1

Caveolin-1

73% ± 3

9% ± 3

GM130

41% ± 5

7% ± 2

Grp 78

38% ± 4

3% ± 2

TfR

6% ± 3

68% ± 8

LAMP-1

9% ± 2

40% ± 6