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The Blue Brain Project: calibrating the neocortical column

  • Sean Hill1, 2Email author,
  • Rajnish Ranjan2,
  • Srikanth Ramaswamy2,
  • Shaul Druckman3,
  • Albert Gidon3,
  • Jie Bao2,
  • Imad Riachi2,
  • Felix Schürmann2 and
  • Henry Markram2
BMC Neuroscience20078(Suppl 2):P110

Published: 6 July 2007


Functional ConnectivityLate DataBiological DataCalibration ProcessElectrical Behavior

The Blue Brain Project is an attempt to reverse-engineer and model the neocortical column, to explore how it functions and to serve as a tool for neuroscientists and medical researchers. In order to achieve the goal of automatically fitting models to the latest data from clearly defined sources, a series of calibration steps have been developed. Each calibration step includes a physiological database, analysis technique and comparison to model data. All data is scored for completeness and quality. The aspects of the neocortical model for which calibration steps have been implemented are: the volume and composition of the column, ion channels, single cell electrical behavior, morphology repair and cloning, synaptic properties, short- and long-term plasticity, synaptic integration, polysynaptic loops, touch detection, structural and functional connectivity and emergent phenomena. The result of the calibration process is a score indicating the overall precision and quality of the fit. This system provides a means to identify those areas which require additional biological data as well as those areas where the model is biologically accurate or in need of refinement. The calibration process will continue to develop, as further biological details become known, and guide the refinement of the neocortical column model.

Authors’ Affiliations

IBM T.J. Watson Research Center, Yorktown Heights, New York, USA
Blue Brain Project, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland
Department of Neurobiology, Hebrew University, Jerusalem, Israel


© Hill et al; licensee BioMed Central Ltd. 2007

This article is published under license to BioMed Central Ltd.