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- Open Access
Age-related neuromorphological distortion affects stability and robustness in a simulated test of spatial working memory
© Coskren et al; licensee BioMed Central Ltd. 2007
Published: 6 July 2007
Normal aging in humans and nonhuman primates is associated with cognitive decline, particularly in tasks involving working memory function that relies on the prefrontal cortex . Because normal aging is not correlated with widespread neuron death or gross morphological degeneration, the biological substrate of these deficits remains unclear . We have constructed a simulated network of model neurons with sufficient detail to model age-related perturbations to morphology and network connectivity, in order to investigate the extent to which these morphological changes in single neurons could explain the functional degradation.
By defining a stability manifold, we demonstrate how stability and robustness can be quantified as a function of biologically relevant perturbations to single cell morphology and network parameters. This provides a novel technique for evaluating the functional significance of local morphological changes, caused by age, disease or injury, upon cognition at the organism scale.
Supported by NIH grants MH071818, DC05669, AG02219, AG05138.
- Gallagher M, Rapp PR: The use of animal models to study the effects of aging on cognition. Annu Rev Psychol. 1997, 48: 339-70. 10.1146/annurev.psych.48.1.339.PubMedView ArticleGoogle Scholar
- O'Donnell KA, Rapp PR, Hof PR: Preservation of prefrontal cortical volume in behaviorally characterized aged macaque monkeys. Exp Neurol. 1999, 160: 300-310. 10.1006/exnr.1999.7192.PubMedView ArticleGoogle Scholar
- Tegnér J, Compte A, Wang X-J: The dynamical stability of reverberatory neural circuits. Biol Cybern. 2002, 87: 471-481. 10.1007/s00422-002-0363-9.PubMedView ArticleGoogle Scholar
- Traub RD, Contreras D, Cunningham MO, Murray H, LeBeau FEN, Roopun A, Bibbig A, Wilent WB, Higley MJ, Whittington MA: Single-column thalamocortical network model exhibiting gamma oscillations, sleep spindles, and epileptogenic bursts. J Neurophysiol. 2005, 93: 2194-2232. 10.1152/jn.00983.2004.PubMedView ArticleGoogle Scholar
- Kabaso D, Nilson J, Luebke JI, Hof PR, Wearne SL: Electrotonic analysis of morphologic contributions to increased excitability with aging in neurons of the prefrontal cortex of monkeys. Program number 237.10. 2006 Abstract Viewer and Itinerary Planner. 2006, Washington, DC: Society for NeuroscienceGoogle Scholar
- Coskren PJ, Hof PR, Wearne SL: Stability and robustness in an attractor network are influenced by degree of morphology reduction. Poster S.97, CNS*. 2006Google Scholar
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