Factors that regulate embryonic gustatory development

BMC Neuroscience

Table 1 Timeline of morphological development in the taste system.

Gustatory ganglion	Placode formation	Placode delamination migration	Initial axon outgrowth	Peak cell production	Axons reach tongue	Peak cell death	Target innervation
Mouse	E8.5	E9.5	E9.5	E10.5	E12	E14.5	E14-15
Rat	E9.5-10	E11	E11.5	E12.5	E13.5	E16.5	E16.5
Tongue and taste buds	Tongue	Fungiform papillae (placode) (SEM)	Full no. of fungiform papillae	Taste bud differentiation begins	Taste pores	Full no. of vallate taste buds
Mouse	E12	E13-13.5	E14.5	E16.5	postnatal	adult
Rat	E13.5	E14.5-15.5	E16.5	E20.5	postnatal	adult

A general timetable of major morphological changes is provided for rats and mice. The first sperm/plug positive day is considered day 0.5. Mice typically develop two days earlier than rats. The bold time points have been determined experimentally, non-bold numbers are estimated values based on this two-day difference.

ISSN: 1471-2202