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Figure 5 | BMC Neuroscience

Figure 5

From: Alterations in the Notch4 pathway in cerebral endothelial cells by the HIV aspartyl protease inhibitor, nelfinavir

Figure 5

HIV PIs do not affect APP expression in CEC. A) Western analyses of the expression of total APP after 5 μM exposure to A) saquinavir (SQV), indinavir (INV), nelfinavir (NFV), and ritonavir (RTV) for various lengths of time (1, 24, 48 and 96 h). B) quantitative real-time PCR analyses of APP mRNA levels after exposure to saquinavir (S), indinavir (I), nelfinavir (N), or ritonavir (R) for 1 or 48 h. No statistically significant differences were calculated by one way ANOVA. Graphs reflect results from three or more separate experiments.

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