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Figure 7 | BMC Neuroscience

Figure 7

From: Development of transgenic rats producing human β-amyloid precursor protein as a model for Alzheimer's disease: Transgene and endogenous APP genes are regulated tissue-specifically

Figure 7

Gene expression analysis of APP-transgenic mice. A. Northern blot hybridization of total RNA from C3-3 APP-transgenic mouse tissues. Total RNA hybridized with a human APP probe (upper autoradiogram) prior to hybridization with 18S rRNA (lower autoradiogram). B. Gene expression differences among organs obtained from C3-3 mice. The expression of APP genes was normalized by dividing the net intensity of APP bands by the 18S rRNA bands. Different letters above the bars represent statistically significant (P < 0.05) expression levels. B: Brain, H: Heart, K: Kidney, Li: Liver, Lu: Lung.

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BMC Neuroscience

ISSN: 1471-2202

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