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Figure 3 | BMC Neuroscience

Figure 3

From: Carbenoxolone induced depression of rhythmogenesis in the pre-Bötzinger Complex

Figure 3

Steady-state I K (I Kd ) remains near baseline values during treatment with Glycyrrhizic acid or Carbenoxolone. A. Representative whole cell voltage clamp traces demonstrating the lack of significant change in IK over time (20 min) in aCSF or GZA (50 μM). Horizontal scale bar = 20 ms; vertical scale bar = 1 nA. Black trace represents control conditions and red trace represents drug effect. B. Current Density vs. voltage relationships during the baseline (t = 0 min) sample and after 20 min in the indicated treatment. C. Current density evoked during voltage steps from -60 to 30 mV remained similar to baseline value during treatment with CBX or GZA. The numbers within each column represent sample size.

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