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Table 1 Effects of aCSF, GZA and CBX treatment on resting membrane properties of preBötC neurons.

From: Carbenoxolone induced depression of rhythmogenesis in the pre-Bötzinger Complex

Condition

n

Input Resistance1(Rin; MΩ)

Holding Current2(Ihold; pA)

aCSF

   

   0 min

10

339.1 ± 66.4

-60.8 ± 14.9

   5 min

10

362.8 ± 126.1

-73.7 ± 14.9

   10 min

10

327.2 ± 63.4

-71.2 ± 14.9

   15 min

10

358.1 ± 122.1

-73.7 ± 13.5

   20 min

10

329.2 ± 82.4

-82.7 ± 13.6

GZA (50 μM)

   

   0 min

11

308.2 ± 66.2

-67.3 ± 8.4

   5 min

11

232.4 ± 91.9

-110.4 ± 29.8

   10 min

11

212.0 ± 41.2

-125.8 ± 25.9

   15 min

11

182.9 ± 79.3

-160.8 ± 31.9

   20 min

11

160.0 ± 29.5

-200.0 ± 38.7

CBX (50 μM)

   

   0 min

8

387.6 ± 48.5

-53.9 ± 7.9

   5 min

8

238.7 ± 41.5

-73.8 ± 7.3

   10 min

8

260.3 ± 78.1

-116.3 ± 29.8

   15 min

7

237.7 ± 56.0

-99.4 ± 14.4

   20 min

7

197.2 ± 40.4

-168.9 ± 48.7

  1. All values shown were obtained from neurons in the presence of CdCl2 and comparison was performed between values for respective time intervals.
  2. 1Input resistance decreased for both CBX- and GZA-treated neurons over time (Friedman's Repeated Measures ANOVA on ranks for CBX: df = 4, SS = 393977.8, MS = 98494.5, F = 2.798, P = 0.040; Friedman's Repeated Measures ANOVA on ranks for GZA: df = 4, SS = 137567.026, MS = 34391.757, F = 3.457, P = 0.023).
  3. 2Compared using Kruskal-Wallace ANOVA on Ranks (H = 44.93, d.f. = 14, P < 0.001).