Creatinine (A) levels in plasma, creatine levels in brain (B-E), muscle creatine (F) of animals in Experiment 2 (mean ± SEM expressed as a percent of control). Forced swim animals demonstrated decreased creatinine levels compared to control animals at 1 and 7 h (A). No overall differences in creatine levels between forced swim and control animals were observed in hippocampus (B), neostriatum (C), or prefrontal cortex (D) In the cerebellum (E) there was a decrease in creatine (inset in E). No differences in muscle creatine levels were observed between forced swim and control animals (F). * p ≤ 0.05 vs control.