From: Identification of a set of genes showing regionally enriched expression in the mouse brain
Brain Regions/Cell types | Example Processes/Disease Associations | Genes |
---|---|---|
Cortex | Alzheimer Disease, Amyotropic Lateral Sclerosis, Plasticity | B3galt2, 3110035E14Rik, Ccl27, Ctgf, Emx1, Fhl2, Klf10, Myl4, Rbp4, Rtn4rl2, Stx1a, Tbr1, Vip, Ddit4l, Dkkl1, Rspo2, Ier5, Igfbp6, Ephb6, Mpped1, Pak7, Satb2, Cplx3, E430002G05Rik |
Hippocampus | Alzheimer Disease Adult Neurogenesis, Depression, Plasticity | Htr1A, Tgfb2, Gria1, Nr3c2 |
Hippocampus, Ammon's Horn | Alzheimer Disease Adult Neurogenesis, Depression, Plasticity | Hunk, Klk8, Gpr161, Arfrp2, C630041L24Rik, Slc9a2, Neurod6, Pkp2, Fibcd1, Sstr4 |
Hippocampus, Dentate Gyrus | Alzheimer Disease Adult Neurogenesis, Depression, Plasticity | Gabrd, Prox1, Dsp, C78409, Lct, Crlf1, Tdo2, A330019N05Rik, Lrrtm4, Htr4, Tspan18 |
Neurogenic Regions | Adult Neurogenesis | Nr2e1, Dcx, Mki67, Vim, Dlx2, Nes, Dlx1, Dscam, Fabp7, Igfbpl1, Lrrn1, Rrm1, Sox2, Thbs4 |
Striatum | Huntington Disease, Parkinson Disease, Plasticity in Depression | Adora2a, Gpr88, Drd1a, Drd2, Gpr6, Rgs9, Adcy5, Crym, Foxp1, Lpl, Pde1b1, Pdyn, Rarb, Rasd2, Tgfa |
Amygdala | Huntington Disease, Depression, Plasticity | Tac1, Cyp26b1, Hap1, Cdh9, Ptprc, Gabra2, Hgf, Pdzrn3, Plxnd1, Wwox, Rasal1, Dock10, Prkcd |
Amygdala, Basolateral Complex | Huntington Disease, Depression, Plasticity | Grp, Nov, Nr2f2 |
Amygdala, Central Nucleus | Huntington Disease, Depression, Plasticity | Atp6v1c2 |
Thalamus | Huntington Disease | Ramp3, Rgs16, Slitrk6, Tnnt1, 1110069I04Rik Amotl1, Rab37, Sh3d19, Grid2ip, Lef1, Plekhg1, Syt9, Tcf7l2, Gm804, Gja7, Socs6, Vangl1 |
Hypothalamus | Cancer | Hcrt, Gpx3, Trh, Fezf1, Agrp, Calcr, Ghrh, Npy, Pmch, Pomc |
Cerebellum, Granule Cells | Medulloblastoma, Ataxia, Cerebellar hypoplasia | Gabra6, Cbln3 |
Cerebellum, Purkinje Cell Layer | Spinocerebellar Ataxia, Autism, Plasticity | Pcp2, Hbegf, Icmt, Atp2a3, Casq2, Gdf10, Grid2, Hes3, Lhx1, Ptprm, A930006D11Rik |
Basal Nucleus of Meynert | Acetylcholine System, Alzheimer Disease | Gal, Ngfr, Tac2, Lhx8, Ecel1, Gbx1, Lancl3, Ntrk1 |
Substantia Nigra | Dopamine System, Parkinson Disease | Ddc, Slc6a3, Ntsr1, Pitx3, Aldh1a1, Chrna6, Chrnb3, Th |
Raphe Nuclei | Norepinephrine System, Depression | Fev, Gchfr, Slc6a4, Slc17a8, Tph2, Maob, Esr2 |
Locus Coeruleus | Serotonin System, Depression | Dbh, Maoa, Slc6a2, Slc18a2 |
Astroglia | Alzheimer Disease | Gfap, S100b, Slc1a2, Plaur, Gcm1, Gcm2, Serpina3n |
Microglia (activated) | Alzheimer Disease, Amyotropic Lateral Sclerosis | Cd68, Aif1, P2rx7, Sulf2 |
Microglia (constitutive) | Alzheimer Disease | Cx3cr1, Itgam |
Oligodendroglia | Alzheimer Disease, Multiple Sclerosis | Olig1, Ugt8a, Cnp, Gjb1, Klk6, Mag, Apod, Enpp2, Fa2h, Mal, Mbp, Mobp, Mog, Olig2, Pllp, Plp1, Sox10, Tmem63a |
Barrington's Nucleus | Pain | Crh, Fgfr1 |
Brainstem, Pons and Medulla | Pain | Slc6a5, Glra1, Pogz, Anxa4, Spp1, Esr1, Pou4f1, Slc4a2, Stac |
Cortex, Anterior Cingulate | Pain | Egr1, Stmn1, Cckbr,Adcy1 |
Cortex, Somatosensory | Pain | Rspo1, Cyp39a1, Cartpt, Col5a1, Rorb, Loc433228, Gnb4 |
Cortex, Insula | Pain | Lxn, Ntng2, Nr4a2, Fezf2, Ttc9b |
Hypothalamus, Paraventricular Nucleus | Pain | Avp, Oxt |
Subthalamic Nucleus | Pain | Pitx2, Lmx1b |
Blood Brain Barrier | Drug therapy | Abcb1a, Cldn5, Ednra, Fcgrt, Hspa12b, Lrp10, Lrp8, Rage, Slc2a1, Slc7a5, Slco1c1, Slc6a12, Slc28a2 |
GABAergic neurons | Schizophrenia, Bipolar Disorder | Vip*, Gpr88‡ |