Figure 6

Down regulated gene expression profiles by K-means clustering analyses. Upper panels: Expression levels of myelin associated genes were lower in cerebellum and cerebrum of PS-/- mice at 20–25 days compared to WT mice. Middle and Lower panels: Purkinje cell genes, Calbindin (Calb1) and Pcp2, had increase of expression in WT cerebellum with age. Expression of Calb1 and Pcp2 decreased in the cerebellum of PS-NA and 4L/PS-NA mice by 12 wks. Grid2 that also expressed in Purkinje cells was only decreased in 4L/PS-NA cerebellum. In PS-NA and 4L/PS-NA cerebrum, Clasp2, Creg2 and Kcnn2 were decreased compared to WT. Expression profiles for each cluster are shown as the log scale ratio of signal intensity to the median signal intensity across all samples with age (days or weeks). The right side tables show the genes in the clustering.