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Table 4 Functional classification of significantly expressed genes in cerebellum and cerebrum of prosaposin deficient mouse models

From: Temporal gene expression profiling reveals CEBPD as a candidate regulator of brain disease in prosaposin deficient mice

 

PS-/-

PS-NA

4L/PS-NA

Categories

Cerebellum

Cerebrum

Cerebellum

Cerebrum

Cerebellum

Cerebrum

 

No.

p-value

No.

p-value

No.

p-value

No.

p-value

No.

p-value

No.

p-value

Inflammation & Macrophage

34

1.10E-09

23

3.75E-04

80

1.59E-14

39

4.80E-12

147

5.53E-13

78

5.01E-13

Myelination

14

3.57E-11

13

8.21E-10

8

2.07E-03

2

*2.33E-01

11

1.19E-02

6

6.75E-03

Synapse vesicle

5

3.23E-02

14

7.75E-07

14

3.87E-04

4

*1.53E-01

35

3.63E-09

6

*8.86E-02

Cell death

13

8.94E-03

11

4.21E-02

20

1.22E-02

10

4.16E-02

50

4.83E-05

19

1.62E-03

Lipid metabolism

19

1.89E-03

22

2.91E-04

28

6.04E-03

15

3.22E-02

68

1.60E-05

31

9.57E-06

ECM/adhesion

18

1.43E-02

28

1.31E-05

55

8.58E-11

23

8.93E-04

107

7.25E-15

36

2.45E-06

Cytoskeleton organization

15

4.43E-02

20

9.32E-03

20

2.06E-02

19

1.55E-02

57

3.16E-02

26

5.79E-03

Endosome/Lysosome

12

1.32E-04

15

2.90E-06

17

1.96E-04

11

7.06E-04

32

2.11E-05

20

7.99E-08

Signal transduction

50

3.50E-03

75

2.83E-09

131

7.66E-14

68

5.37E-07

288

2.24E-14

89

4.82E-08

Transcription

67

1.70E-02

65

3.92E-02

134

7.55E-04

77

2.43E-03

292

1.01E-04

90

2.09E-02

Transport

69

2.20E-04

80

2.94E-06

108

4.10E-03

69

7.34E-04

288

9.01E-11

83

4.46E-03

Cell growth/metabolism

139

4.31E-10

204

3.13E-14

301

3.28E-07

189

9.13E-10

714

1.98E-13

237

2.87E-08

Binding

142

4.54E-06

172

2.96E-12

278

9.53E-12

169

1.94E-11

641

2.45E-15

201

6.83E-08

Catalytic activity

104

2.57E-03

138

2.96E-09

220

2.70E-08

121

2.68E-05

486

1.90E-13

153

9.12E-05

Others

46

 

25

 

71

 

38

 

171

 

47

 
  1. The functional categories with p-value ≤ 0.05 were considered significant by hypergeometric distribution analyses using R 2.6.0 [56].
  2. No., number of genes.
  3. *, not significant (p > 0.05).
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BMC Neuroscience

ISSN: 1471-2202

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