Skip to main content
Figure 1 | BMC Neuroscience

Figure 1

From: Roles of PI3K and JAK pathways in viability of retinal ganglion cells after acute elevation of intraocular pressure in rats with different autoimmune backgrounds

Figure 1

Representative fluorescent photomicrographs of retinal wholemounts showing characteristics of retrogradely FG-labeled surviving RGCs (left column) and ED1+ macrophages (right column). A and B, normal F344 rat; C and D, after application of pathway inhibitor KY12420 in IOP-elevated F344 rat; E and F, after application of pathway inhibitor KY12420 and clodonate liposomes in IOP-elevated F344 rat; G and H, normal Lewis rat; I and J, after application of pathway inhibitor KY12420 in IOP-elevated Lewis rat; K and L, after application of pathway inhibitor KY12420 and clodonate liposomes in IOP-elevated Lewis rat. More surviving RGCs were seen in F344 than Lewis rats after IOP elevation and pathway inhibition (C versus I). After removal of macrophages by clodronate liposomes, the numbers of surviving RGCs increased in both F344 (E versus C) and Lewis (K versus I) rats. Similar results were obtained after inhibition of JAK/STAT pathway (images not shown). Scale bar = 50 μm.

Back to article page

BMC Neuroscience

ISSN: 1471-2202

Contact us