Skip to main content
Figure 2 | BMC Neuroscience

Figure 2

From: Roles of PI3K and JAK pathways in viability of retinal ganglion cells after acute elevation of intraocular pressure in rats with different autoimmune backgrounds

Figure 2

Average densities (± SEM) of FG-labeled surviving RGCs and ED1+ macrophages after inhibition of PI3K/akt and JAK/STAT pathways in F344 rats. Significant decrease in RGC viability and concomitant increase in the number of macrophages were seen following PI3k/akt and JAK/STAT pathway inhibition (A). After macrophage removal (B), pathway inhibition-induced RGC loss was significantly but not completely prevented, indicating that both macrophage and PI3k/akt and JAK/STAT pathways were involved in RGC viability in this strain of rat. *p < 0.05, **p < 0.01 and ***p < 0.001 against DMSO group unless specified.

Back to article page