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Table 1 Antibodies Employed in Present Study

From: Detailed immunohistochemical characterization of temporal and spatial progression of Alzheimer's disease-related pathologies in male triple-transgenic mice

Target Epitope

Antibody (Supplier)

Reference

hAPP

Rabbit monoclonal clone Y188

-

Amyloid precursor protein A4, corresponding to the NPXY motif of hAPP

(Abcam)

 

hAPP/Aβ

Mouse monoclonal clone 6E10

Götz J, et al. [70]

Aβ amino acid residues 1–16; also cross-reacts with hAPP

(Signet)

Hock C, et al. [71]

  

Oddo S, et al. [72]

hAβ 1–42 (extracellular) C-terminus of Aβ 1–42

Mouse monoclonal clone 12F4

Parvathy, S., et al. [73]

 

(Covance/Signet)

 

hAβ 1–42 (intracellular) C-terminus of Aβ 1–42

Rabbit polyclonal anti Aβ 1–42

D'Andrea, et al [27]

 

(Biosource/Invitrogen)

 

hTau

Mouse monoclonal HT7

Oddo et al [18]

Human Tau amino acid residues 159–163

(Pierce)

Mercken M et al [74]

Phosphorylated Tau

Mouse monoclonal AT180

Greenberg and Davies [39]

Human Tau phosphorylated residue Thr231

(Pierce)

Oddo S et al. [18]

Paired Helical Filaments

Monoclonal mouse anti-PHF-1

Ksiezak-Reding, et al. [37]

Human Tau phosphorylated on amino acid residues Ser396 and Ser404 associated with paired helical filaments

(Dr. Peter Davies, Albert Einstein School of Medicine)

Clinton, et al. [68]

F4/80

Rat anti mouse F4/80

Janelsins et al. [52]

 

(AbD Serotec)

 

Cell surface glycoprotein on mature macrophages that is a member of the EGF-TM7 family

  

GFAP

Rabbit polyclonal anti-GFAP

Shaftel S, et al. [75]

Cell surface marker (glial fibrillary acidic protein) for mature astrocytes

(Dako Cytomation)

Â