Figure 1
From: A neural-glial network for modeling spreading depression in cortex
Left panel Model neuron-astrocyte network in which astrocytic transmission is effected by ATP and neuronal transmission by glutamate: from astrocyte to neuron by glutamate (GluA) acting on NMDA receptors; from neuron to astrocyte by glutamate (GluB) acting on metabotropic receptors; from neuron to neuron by glutamate (GluC) acting on AMPA receptors; from astrocyte to astrocyte by ATP acting on P2Y receptors. Right panel Time course of K+ concentration in neurons, extracellular space and astrocytes, respectively; traces are for the first seven cells in the network.