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Intermittent patterns of synchronous activity in human basal ganglia
© Park et al; licensee BioMed Central Ltd. 2008
Published: 11 July 2008
Basal ganglia (BG) are involved in control of movement and are impacted in Parkinson's disease (PD). This impact is believed to be responsible for the symptoms. Recent studies provided evidence for the significance of oscillatory activity in beta and gamma bands for BG physiology in both health and disease, such as PD and dystonia [1, 2]. The dynamics of the oscillations and their mechanisms are the subjects of this study.
We record intraoperatively from subthalamic nucleus (STN) of patients undergoing stereotactic surgery in PD. We use the network of conductance based models of excitatory subthalamic and inhibitory pallidal cells (following ) to study intermittent activity in the model of BG circuits. We rely on the approach of detection of statistically significant episodes of phase-locking activity developed by us and colleagues  to characterize intermittent patterns of synchronous activity between spiking units and local field potentials (LFP) in the data and the model.
The properties and mechanisms of the intermittent activity as well as its functional significance are discussed.
Supported by Indiana University Purdue University Indianapolis RSFG grant.
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