Figure 2

Comparison of the whole brain phase values between the patients with mTLE and healthy controls. A: One-sample t-test for processed phase images in all subjects. It is apparent that the sub-cortical nuclei, including the globus pallidus, substantia nigra and red nucleus showed lower phase values (or higher iron concentration) than the other brain structures. B: Two sample t-tests analyses revealed increased iron concentration in mTLE in the neocortex, and decreased iron concentration in the subcortical structures. SWI phase value were decreased in multiple cortical regions in mainly frontal, temporal and occipital lobes; increased SWI phase was found in sub-cortical structures including the bilateral GPi, RN and SN. Finding have been thresholded at P < 0.05, FDR correction. The results are shown by overlying on MNI 305 template image. Abbreviations: L: left; R: right; PUT: putamen; GPi: internal globus pallidus; SN: substantia nigra; RN: red nucleus.