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Table 2 Sojourn times and Normalized Transition Rates (NTR) in the steady phase

From: Chronic escitalopram treatment attenuated the accelerated rapid eye movement sleep transitions after selective rapid eye movement sleep deprivation: a model-based analysis using Markov chains

Steady phase (2001-7200 s)

Group

WAKE

NREM

REM

 

Sojourn time (s)

L

U

Sojourn time (s)

L

U

Sojourn time (s)

L

U

RD-SSRI

25.939 *#

22.668

29.681

49.719

44.440

55.625

43.633 #&

35.921

53.001

HC-SSRI

17.051

14.901

19.511

54.452

48.670

60.921

65.816 *

54.183

79.946

RD-VEH

23.081 *

20.442

26.061

40.459

36.157

45.273

20.999 *

18.379

23.994

HC-VEH

17.199

15.031

19.681

46.758

41.793

52.312

32.844

27.039

39.896

 

WAKE → NREM

NREM → WAKE

   
 

NTR

L

U

NTR

L

U

   

RD-SSRI

0.631 *#

0.528

0.755

0.836

0.696

1.005

   

HC-SSRI

0.970

0.819

1.150

0.938

0.800

1.099

   

RD-VEH

0.685 *

0.573

0.819

0.831 *

0.695

0.993

   
 

WAKE → REM

REM → WAKE

   
 

NTR

L

U

NTR

L

U

   

RD-SSRI

0.940

0.562

1.573

0.820

0.535

1.255

   

HC-SSRI

1.347

0.822

2.206

0.518 *

0.282

0.951

   

RD-VEH

1.277

0.768

2.123

1.208

0.853

1.710

   
 

NREM → REM

REM → NREM

   
 

NTR

L

U

NTR

L

U

   

RD-SSRI

1.274 #&

0.975

1.665

0.709 &

0.497

1.013

   

HC-SSRI

0.605 *

0.453

0.806

0.486 *

0.297

0.796

   

RD-VEH

2.198 *

1.739

2.779

1.796 *

1.382

2.334

   
  1. Sojourn time: the estimated mean of the average time span of an event;
  2. Normalized Transition Rate (NTR): relative transition rate compared to the HC-VEH group (NTR of the HC-VEH group is 1);
  3. L and U: lower and the upper limits of the corresponding 95% confidence interval, respectively;
  4. * p < 0.05, significant effect compared to the HC-VEH group;
  5. #p < 0.05, significant effect compared to the HC-SSRI group;
  6. &p < 0.05, significant effect compared to RD-VEH group;
  7. Groups: home cage plus chronic vehicle treatment (HC-VEH); home cage plus chronic escitalopram treatment (HC-SSRI); REM sleep deprivation plus chronic vehicle treatment (RD-VEH); REM sleep deprivation plus chronic escitalopram treatment (RD-SSRI).
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BMC Neuroscience

ISSN: 1471-2202

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