| Two-way ANOVA | mean ± SEM | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Treatment effect | Rebound effect | Treatment x Rebound | |||||||||
F 1,23 | p | F 1,23 | p | F 1,24 | p | HC-VEH | RD-VEH | HC-SSRI | RD-SSRI | ||
Total time spent in stage | WAKE | 0.97 | 0.3337 | 2.00 | 0.1703 | 0.89 | 0.3529 | 2063.0 ± 208.2 | 2991.0 ± 337.2 | 2823.0 ± 444.4 | 3006.0 ± 473.7 |
NREM sleep | 0.0008 | 0.9772 | 11.08 | 0.0029 | 1.14 | 0.2963 | 4325.0 ± 152.8 | 2921.0 ± 195.7 * | 3975.0 ± 430.1 | 3253.0 ± 367.8 | |
REM sleep | 9.18 | 0.0066 | 15.85 | 0.0007 | 0.10 | 0.7502 | 680.8 ± 58.8 | 1470.0 ± 160.9 * | 401.7 ± 69.0 | 940.6 ± 236.3 | |
 | SLEEP | 0.97 | 0.3335 | 2.00 | 0.1706 | 0.89 | 0.3527 | 5136.6 ± 208.2 | 4209.1 ± 337.2 | 4376.5 ± 444.8 | 4193.7 ± 473.7 |
Number of stage episodes | WAKE | 1.45 | 0.2393 | 2.03 | 0.1673 | 0.08 | 0.7757 | 44.5 ± 5.3 | 39.2 ± 4.5 | 40.2 ± 3.8 | 32.4 ± 4.5 |
NREM sleep | 0.96 | 0.3354 | 0.08 | 0.7717 | <0.0001 | 0.9924 | 71.5 ± 16.5 | 74.8 ± 9.5 | 60.7 ± 6.1 | 63.8 ± 11.2 | |
REM sleep | 7.56 | 0.0117 | 25.22 | <0.0001 | 0.71 | 0.4071 | 11.4 ± 0.7 | 16.1 ± 0.4 | 5.0 ± 1.1 | 13.43 ± 2.0 ## | |
 | SLEEP | 0.63 | 0.4330 | 1.71 | 0.2035 | 0.26 | 0.6119 | 71.5 ± 17.3 | 53.1 ± 7.5 | 58.2 ± 6.2 | 50.2 ± 7.9 |
Average duration of stage episodes | WAKE | 0.75 | 0.3925 | 2.84 | 0.1024 | 0.15 | 0.7013 | 34.6 ± 6.0 | 64.5 ± 14.8 | 52.6 ± 12.2 | 71.4 ± 18.8 |
NREM sleep | 0.08 | 0.7756 | 5.74 | 0.0250 | 0.65 | 0.4284 | 74.27 ± 14.0 | 43.5 ± 7.1 | 69.3 ± 11.0 | 54.0 ± 4.7 | |
REM sleep | 0.19 | 0.6664 | 13.49 | 0.0015 | 0.04 | 0.8299 | 41.6 ± 6.8 | 25.1 ± 4.1 | 44.8 ± 4.0 | 26.2 ± 4.2 # | |
 | SLEEP | 0.05 | 0.8139 | 0.24 | 0.6229 | 0.09 | 0.7580 | 88.8 ± 16.4 | 91.8 ± 18.3 | 79.9 ± 12.2 | 93.0 ± 16.91 |
Sleep fragmentation | 0.64 | 0.4308 | 1.72 | 0.2022 | 0.28 | 0.5997 | 71.0 ± 17.4 | 52.4 ± 7.4 | 57.5 ± 6.2 | 49.7 ± 7.8 | |
REM sleep latency | 5.05 | 0.0359 | 16.53 | 0.0006 | 0.10 | 0.7519 | 1285.6 ± 171.6 | 280.0 ± 57.1 * | 2755.4 ± 480.7 | 1187.4 ± 410.7 # | |
Sleep (SWS-1) latency | 0.06 | 0.7992 | 0.38 | 0.5385 | 2.54 | 0.1244 | 820.7 ± 189.5 | 1321.0 ± 229.3 | 1122 ± 257.1 | 903.4 ± 206.9 | |
First REM item | 0.30 | 0.5848 | 0.15 | 0.7005 | 0.50 | 0.4860 | 78.4 ± 17.2 | 102.0 ± 24.5 | 81.7 ± 20.5 | 74.8 ± 20.4 |