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Figure 3 | BMC Neuroscience

Figure 3

From: Defects in the retina of Niemann-pick type C 1 mutant mice

Figure 3

Electron micrographs of Npc1 -/-retinae. A, B: In the inner nuclear layer (INL), bipolar cells (BC) and darkly stained Müller cell (MC) as well as endothelial cell (arrowhead in A) contain electron- dense deposits. Bipolar cells in B are marked yellow. C, D: Electron- dense deposits are also found in the endothelial cell (EC) of the Npc1-/- retina (D), but not in wild type animals (C). Tight junctions in the capillary between endothelial cells appear to be intact (arrows in D). E, F: In the outer nuclear layer (ONL) of the Npc1-/- retina, the interface area (arrow) between inner (iS) and outer (oS) segments (E) and the cilia (Ci) linking outer and inner segments (F) of photoreceptor cells appear normal. In contrast to earlier observations detecting with immunohistochemistry [22], we did not encounter disorganized membrane stacks of oS. Scale bars: 2.5 μm in A; 1 μm in B-D; 500 nm in E, F.

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