Figure 6

Defected bipolar cells in the Npc1 ^-/-retina. Retinal sections from P65 Npc1^+/+ and Npc1^-/- mice were immunostained with antibodies against PKCα (A-F) and Goα (G-L). Nuclei were stained with DAPI (blue). B, E, H, K show magnification of the INL of retina from A, D, G, J, respectively. C, F, I, L show magnification of the INL from A, D, G, J, respectively. Abbreviations: ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer; IPL, inner plexiform layer; GCL, ganglion cell layer. Scale bar: 10 μm in B for B, E, H, K and in C for C, F, I, L; 40 μm in A for A, D, G, J.