Figure 8
From: Defects in the retina of Niemann-pick type C 1 mutant mice
Activated astrocytes and Müller cells in the Npc1 -/-retina. Retinal sections from P65 Npc1+/+ and Npc1-/- mice were immunostained with antibodies against GFAP (A-F) and glutamine synthetase (G-L). Nuclei were stained with DAPI (blue). C, F show magnification of immuno-positive areas from A, D, respectively. H, K show magnification of the ONL, and I, L of the IPL and GCL from G, J, respectively. Abbreviations: ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer; IPL, inner plexiform layer; GCL, ganglion cell layer. Scale bar: 10 μm in C for C, F and in H for H, I, K, L; 50 μm in A for A, B, D, E, G, J.