The effect of hypertension on outcome following MCAO and progesterone treatment. The percentage of animals survived post-surgery over time (A). Mortality data expressed using the Kaplan-Meier curve and analysed using the Mantel-Haenszel log-rank test showed no significant difference between groups in % of surviving animals. All BPH/2 mice significantly lost body mass after surgery (P = 0.0001) but progesterone treatment did not affect the amount of body mass loss (B). Progesterone treatment reduced neurological deficit (C) compared to controls (***P = 0.0001). Contralateral foot-faults (%) were assessed in BPH/2 mice on the day following surgery (D) and there was no difference found between progesterone and non-treated mice (P = 0.0679). Number of animals per group are shown in parentheses and all data (B-D) are expressed as mean ± SEM.