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Table 2 T-maze data for animals following MCAO

From: Evaluating the translational potential of progesterone treatment following transient cerebral ischaemia in male mice

   Sham Progesterone Vehicle/Non-treated
Day Outcome Adult C57 Bl/6 Adult C57 Bl/6 Hypertensive Adult C57 Bl/6 Hypertensive
5 % Alternation    16.67 ± 7.45   33.33 ± 16.67
  % Contralateral/Ipsilateral Ratio    34.29 ± 12.45   61.90 ± 20.76
  Time Taken (mins)    3.31 ± 0.27   3.81 ± 0.27
6 % Alternation    16.67 ± 10.54   11.11 ± 11.11
  % Contralateral/Ipsilateral Ratio    25.71 ± 17.14*   95.24 ± 4.76
  Time Taken (mins)    3.51 ± 0.27*   5.52 ± 0.80
7 % Alternation 58.34 ± 4.81 38.89 ± 12.67 26.67 ± 16.33 50.00 ± 9.62 33.33 ± 19.25
  % Contralateral/Ipsilateral Ratio 57.14 ± 5.83 54.62 ± 14.03 17.14 ± 10.50 57.14 ± 14.29 71.43 ± 14.29
  Time Taken (mins) 7.78 ± 0.94 6.27 ± 0.91 3.84 ± 0.35* 5.59 ± 0.21 5.59 ± 0.76
  1. There was no significant difference between groups in terms of % alternation rate, contralateral/ipsilateral alternation ratio (%), or time taken to complete trials in adult mice (progesterone n = 6, vehicle n = 3, sham n = 4). In hypertensive BPH/2 mice, there was no difference found between progesterone and non-treated groups in t-maze alternation %, but progesterone treated animals had a significantly greater contralateral goal arm preference than non-treated groups (P = 0.0006). Data expressed as mean ± SEM (progesterone n = 5, vehicle n = 4).