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Figure 1 | BMC Neuroscience

Figure 1

From: Anticonvulsant effects of mefloquine on generalized tonic-clonic seizures induced by two acute models in rats

Figure 1

Mefloquine decreases the incidence of generalized tonic-clonic seizures and increases the percentage of survival. A) The intraperitoneal administration of mefloquine (MFQ) significantly decreases the incidence of generalized tonic-clonic seizures (GTCS) and B) significantly increases the percentage of survival after the administration of pentylenetetrazole (PTZ). The level of significance (*p < 0.05) was determined by independent Fisher’s exact probability tests comparing each experimental group versus control vehicle group. Vehicle + PTZ (n = 8), MFQ 20 mg/kg + PTZ (n = 8), MFQ 40 mg/kg + PTZ (n = 8), MFQ 80 mg/kg + PTZ (n = 8).

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