Figure 4

Effects of chloroquine and mefloquine on the generalized seizures induced by pentylenetetrazole and maximal electroshock. A) Chloroquine (CRQ) did not protect against the generalized tonic-clonic seizures (GTCS) induced by pentylenetetrazole (PTZ). The level of significance (*p < 0.05) was determined by independent Fisher’s exact probability test comparing each experimental group versus control vehicle group. Vehicle + PTZ (n = 8), MFQ 40 mg/kg + PTZ (n = 8), CRQ 40 mg/kg + PTZ (n = 8). B) CRQ did not modify the incidence of tonic hindlimb extension (THLE) induced by maximal electroshock (MES). However, this drug decreased the duration of THLE but in minor proportion that a similar dose of mefloquine. The level of significance (*p < 0.05) was determined by nonparametric Kruskal-Wallis analysis followed by Dunnet test. Vehicle (n = 6), MFQ 40 mg/kg (n = 6), CRQ 40 mg/kg (n = 6).