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Figure 2 | BMC Neuroscience

Figure 2

From: Simulation of alcohol action upon a detailed Purkinje neuron model and a simpler surrogate model that runs >400 times faster

Figure 2

The 1089 compartment Purkinje neuron model can replicate the spontaneous trimodal firing pattern of real Purkinje neurons. A, Morphology of the Purkinje neuron model. B, Morphology of the model in profile, showing its planar character. C, Spontaneous, single trimodal repeat recorded at the soma, with component Tonic, Burst and Quiescent modes discernible. D, The labelled part of Panel (C) at higher resolution, showing a number of somatic bursts from the Burst firing mode. E, The same period as shown in Panel (C) but recorded from a point in the dendritic tree: Smooth Compartment 2. Its dendritic location is presented in Panel (A). F, The labelled part of Panel (E) at higher resolution, showing a number of high-threshold dendritic Ca2+ spikes. G, Recording from Smooth Compartment 80. H, The labelled part of Panel (G) at higher resolution. I, Recording from Spiny Compartment 1. J, The labelled part of Panel (I) at higher resolution. K, Recording from Spiny Compartment 500. L, The labelled part of Panel (K) at higher resolution. M, Recording from Spiny Compartment 1001. N, The labelled part of Panel (M) at higher resolution. This Figure shows that all points in the dendritic tree have equivalent activity. Panels C, E, G, I, K, M are scaled by the first scale bar (50 mV, 5 s). Panels D, F, H, J, L, N are scaled by the second scale bar (50 mV, 100 ms).

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