Figure 3

The 2 compartment Purkinje neuron model can replicate the spontaneous trimodal firing pattern of the 1089 compartment Purkinje neuron model. A, Spontaneous, single trimodal repeat recorded at the soma of the 1089 compartment model, with the constituent Tonic, Burst and Quiescent modes labelled. The trimodal repeat length is ~20 s, which is within the experimentally reported range. B , The same trimodal repeat as ( A ) but recorded from a point within the dendritic tree (spiny compartment 1001). One can compare panels ( A ) and ( B ) and observe that with no high-threshold spikes in the dendrites, firing is tonic at the soma. With high-threshold dendritic spikes, bursting occurs at the soma. C, Spontaneous, single trimodal repeat recorded at the soma of the 2 compartment model. D, The same trimodal repeat as panel ( C ), but recorded from the dendrite compartment of the 2 compartment model. E, Tonic spiking, at the soma, of the full model. F, Burst firing, at the soma, of the full model. G, High-threshold Ca²⁺ spiking, at the dendrite (spiny compartment 1001), of the full model. H, Tonic spiking, at the soma, of the reduced model. I, Burst firing, at the soma, of the reduced model. J, High-threshold Ca²⁺ spiking, at the dendrite, of the reduced model. Panels A-D are scaled by the first scale bar (30 mV, 5 s); Panels E-J are scaled by the second scale bar (40 mV, 300 ms).