Figure 4From: Gypenosides attenuate the development of L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned rat model of Parkinson’s diseaseEffects of GPS and GP-EX on contralateral rotation behavior in 6-OHDA-lesioned rats. L-DOPA (25 mg/kg, i.p.) and benserazide (15 mg/kg, i.p.) treatment was started 6 weeks after the 6-OHDA-lesion once a day for 22 days. GPS (25 and 50 mg/kg, p.o.) and GP-EX (50 mg/kg, p.o.) were given 30 min prior to L-DOPA treatment once a day for 22 days. The contralateral rotation behavior was monitored for 1 h on the indicated day. The results are expressed as mean ± S.E.M. for 8–10 animals/group. –■–, saline treatment; −□–, L-DOPA; −▲–, L-DOPA + GP-EX (50 mg/kg); −◆–, L-DOPA + GPS (25 mg/kg); −○–, L-DOPA + GPS (50 mg/kg). * P < 0.05 compared with saline-treated group at each treatment day (non-parametric Kruskal-Wallis one-way ANOVA test); † P < 0.05 compared with the score of day-1 (Friedman repeated measures ANOVA test).Back to article page