Figure 7From: Blocking a vicious cycle nNOS/peroxynitrite/AMPK by S-nitrosoglutathione: implication for stroke therapySchematic showing hypothesized nNOS/peroxynitrite-mediated deleterious events and GSNO-mediated targets. IR-induced excitotoxicity and calcium dysregulation cause aberrant nNOS activation, peroxynitrite formation and LKB1/AMPK activation. GSNO treatment of IR blocks the vicious cycle by inhibiting the aberrant activity of nNOS and LKB1/AMPK, leading to neuroprotection and improved neurobehavioral function.Back to article page