Fig. 5
NO production levels in the hippocamus of rats treated with hypoxia alone (black column) and melatonin pretreated (white column) and sacrificed at 0 h, 1, and 3 days of reoxygenation. After hypoxic insult, the NO levels in rat hippocampus are significantly increased. In hypoxic rats pretreated with melatonin, the levels of NO production are markedly reduced as compared with those of rats treated only with hypoxia. The NO levels of saline or melatonin treatment under normoxic condition rats are designed as controls (100 %, indicated by dashed line). *P < 0.05 (Student’s t test) when compared with values (expressed as mean ± SEM) of rats simply treated with hypoxia at the same survival time point