Fig. 3

Evidence for defective vomeronasal function in Mras ^−/− mice. a Urine spot investigations. WT mice, but not Mras ^−/− mice, spent more time investigating an unfamiliar (congenic) over a familiar (isogenic) urine spot (left panel) and visited the unfamiliar spot more frequently (right panel). Data is shown with SEM; n = 11 for males, n = 12 for females; one-sample t-tests: WT females: p = 0.0263 (time), p = 0.0122 (# investigations); Mras ^−/− males: p = 0.0409 (time), p = 0.0107 (# investigations); all others, not significant. b Parental offspring recognition test. Mras ^−/− fathers, in contrast to WT fathers, were unable to discriminate between their own offspring and an unrelated isogenic mouse. One-sample t-tests: WT: p = 0.0205, n = 7; Mras ^−/−: not significant, n = 8