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Table 1 Urine metabolomics analysis

From: Absence of M-Ras modulates social behavior in mice

NMR

Metabolite

Fold change in Mras −/− urine

Glycerate

+15.2

Methionine

+6.5

Ascorbate

+4.1

N-Carbamoyl-β-alanine

+3.9

N,N-Dimethylglycine

+3.1

Hypoxanthine

+2.8

Isoleucine

+2.6

Betaine

+2.6

Tyrosine

+2.5

2-Oxcisocaproate

+2.2

Trimethylamine

+2.0

Succinate

-4.8

1-Methlynicotinamide

−2.5

N-Phenylacetylglycine

−2.4

Hippurate

−2.2

Acetoacetate

−2.0

DI-MS

Metabolite group

# Metabolites analyzed

Increased >2-fold in Mras −/− urine

Decreased >2-fold in Mras −/− urine

Acyl carnitines

40

1 (2.5 %)

1 (2.5 %)

Phosphatidylcholines

59

38 (64.4 %)

5 (8.5 %)

Lysophosphatidylcholines

7

3 (42.9 %)

1 (14.3 %)

Sphingomyelins

9

1 (11.1 %)

4 (44.4 %)

  1. WT and Mras −/− male urine samples were analyzed by NMR and direct-injection mass spectrometry (DI-MS). Total number of metabolites analyzed by NMR: 65; DI-MS: 116. Some differences in relative metabolite quantities were confirmed by gas chromatography (GC)-MS analysis: Glyceric acid: +13.5; l-tyrosine: +2.41; succinic acid: −3.85; hippuric acid: −2.17 (fold-change in Mras −/− urine)